Can Flu Vaccine Improve COVID Threat?

For years, considerations have been raised that earlier flu vaccination appears to extend sufferers’ threat of contracting extra extreme pandemic sickness. This occurred in the course of the 2008 to 2009 flu season, when prior vaccination with the seasonal flu vaccine was related to an elevated threat of H1N1 “swine flu” throughout spring/summer season 2009 in Canada.1

A January 2020 research revealed within the journal Vaccine additionally discovered folks have been extra prone to get some type of coronavirus an infection if that they had been vaccinated in opposition to influenza in the course of the 2017 to 2018 flu season.2

In comparison with unvaccinated people, those that had obtained a seasonal flu shot have been 36% extra prone to contract unspecified coronavirus an infection (it didn’t particularly point out SARS-CoV-2, the coronavirus that causes COVID-19) and 51% extra prone to contract human metapneumovirus (hMPV) an infection, which has signs just like COVID-19.3

Once more, in October 2020, one other optimistic affiliation was discovered between COVID-19 deaths and flu vaccination charges within the aged,4 elevating additional questions in regards to the doubtlessly critical unintended negative effects of annual flu photographs.

Flu Vaccination Linked to Elevated Threat of COVID-19 Loss of life

Christian Wehenkel, a professor of forest genetics, forest ecosystem evaluation, forestry, biometrics, forest development and biodiversity with the Universidad Juarez del Estado de Durango, and a PeerJ editor, analyzed knowledge units from 39 nations with greater than one-half million inhabitants.5 He anticipated to search out that prior flu vaccination can be linked to decrease COVID-19 loss of life threat, however as a substitute the information revealed the alternative.

Amongst folks aged 65 years and older, flu vaccination was positively related to COVID-19 deaths, which means those that acquired a flu vaccine have been extra prone to die from COVID-19. “Opposite to expectations, the current worldwide evaluation and European sub-analysis don’t help the beforehand reported unfavorable affiliation between COVID-19 deaths (DPMI) and IVR [influenza vaccination rate] in aged folks,” Wehenkel wrote.

A Could 2020 evaluation by on-line information publication The Gateway Pundit equally discovered that European nations with the best COVID-19 loss of life charges had excessive charges of flu vaccination — a minimum of 50% —  among the many aged.6 As an illustration, they wrote, “Denmark and Germany, with decrease use of the flu vaccine, had significantly decrease Covid-19 mortality.”

They tried to replace their figures for fall 2020, and have been capable of replace COVID-19 mortality charges however didn’t receive present vaccination knowledge. Spikes in COVID-19 deaths have been famous, which they urged may very well be associated to a sudden uptick in flu vaccination in nations that had beforehand decrease vaccination charges:7

“This [increase in COVID-19 deaths] may merely be because of the virus reaching endemic degree later in east Europe, however one other issue may very well be sudden enhance in flu vaccination in counties of hitherto low uptake. Are they unwittingly endangering their seniors?

The World Well being Group is vigorously selling flu vaccination in Europe, with posters warning ‘don’t convey house an undesirable customer: defend your loved ones by getting vaccinated.’ The Covid-19 pandemic has terrified the general public and many individuals see a vaccine as the one technique of escape.”

Wehenkel’s knowledge, nevertheless, picks up the place they left off, exhibiting by scatterplot a transparent affiliation of COVID-19 deaths per million inhabitants with flu vaccination fee, as much as July 25, 2020 (every dot represents a unique European nation):8,9

The Drawback With Pathogenic Priming

Given the PeerJ research’s extremely controversial discovering, which, if confirmed to be causative, would name into query annual flu vaccination, a writer’s word on the high reminds readers that correlation doesn’t essentially imply causation.

“[T]his article shouldn’t be taken to counsel that receiving the influenza vaccination leads to an elevated threat of loss of life for a person with COVID-19 as there could also be many confounding elements at play (together with, for instance, socioeconomic elements),” it reads.10 It additionally doesn’t rule out causation, nevertheless, and it is a potential hyperlink that should be urgently explored. The Gateway Pundit defined:11

“It’s proper to ask the query: are sufferers who die of / with Covid-19 extra prone to have obtained the flu vaccine? Given the clear correlation from Wehenkel’s knowledge, an pressing investigation is required to establish whether or not the massive enhance in Covid-19 deaths in jap Europe within the autumn of 2020 correlates with a rise in flu jabs in autumn 2020 in those self same nations.”

They didn’t cease there:12

“This leads on to the additional explosive query: are flu jabs not solely correlative with Covid-19 mortality, however causative by means of pathogenic priming? If the information from autumn 2020 verify correlation, causation must be investigated with rigor and urgency.”

What’s pathogenic priming? It’s a state of affairs by which, slightly than enhancing your immunity in opposition to the an infection, publicity to a virus or vaccine enhances the virus’ capability to enter and infect your cells, leading to extra extreme illness.13

Analysis revealed within the Journal of Translational Autoimmunity confirmed that therapy with a vaccine could enhance the dangers related to a wild kind virus slightly than defend in opposition to it, and concluded, as its title suggests, “Pathogenic priming seemingly contributes to critical and significant sickness and mortality in COVID-19 by way of automimmunity.”14

Coronavirus Vaccines Have Enhanced Illness within the Previous

The Journal of Translational Autoimmunity article, written by James Lyons-Weiler with the Institute for Pure and Utilized Data, a nonprofit group that performs scientific analysis within the public curiosity, explains how pathogenic priming occurred throughout earlier trials of a SARS coronavirus vaccine:15

“In SARS, a sort of ‘priming’ of the immune system was noticed throughout animal research of SARS spike protein-based vaccines resulting in elevated morbidity and mortality in vaccinated animals who have been subsequently uncovered to wild SARS virus.

The issue, highlighted in two research, grew to become apparent following post-vaccination problem with the SARS virus … recombinant SARS spike-protein-based vaccines not solely failed to supply safety from SARS-CoV an infection, but in addition that the mice skilled elevated immunopathology with eosinophilic infiltrates of their lungs.

Equally … ferrets beforehand vaccinated in opposition to SARS-CoV additionally developed a robust inflammatory response in liver tissue (hepatitis). Each research suspected a ‘mobile immune response.’

All these unlucky outcomes are typically known as ‘immune enhancement’; nevertheless, this almost euphemistic phrase fails to convey the elevated threat of sickness and loss of life as a result of prior publicity to the SARS spike protein. For that reason, I confer with the idea as ‘pathogen priming’.”

On the time, even long-time pro-vaccine advocate Dr. Peter Hotez, dean of the Nationwide Faculty of Tropical Medication and professor of pediatrics and molecular virology and microbiology at Baylor Faculty of Medication, was shaken. In keeping with a characteristic revealed in PNAS:16

“When SARS, additionally a coronavirus, appeared in China and unfold globally almost 20 years in the past, Hotez was amongst researchers who started investigating a possible vaccine.

In early exams of his candidate, he witnessed how immune cells of vaccinated animals attacked lung tissue, in a lot the identical manner that the RSV vaccine had resulted in immune cells attacking children’ lungs. ‘I believed, ‘Oh crap,’’ he remembers, noting his preliminary worry {that a} secure vaccine could once more not be attainable.”

Regardless of years of further analysis and different improvement methods, immune enhancement considerations stay, and, as defined by Robert F. Kennedy, Jr. in our 2020 interview, coronavirus vaccines stay infamous for creating paradoxical immune enhancement.

Wholesome 18-Yr-Outdated Who Died of COVID-19 Received Flu Shot

NBC Information Chicago reported the loss of life of an 18-year-old lady from Tinley Park, Sick., who died from COVID-19 in December 2020 simply three days after being hospitalized.17 It’s the kind of tragic story that strikes worry in tens of millions, however it’s vital to do not forget that one of these loss of life is extraordinarily uncommon.

The COVID-19 survival fee amongst newborns to age 19 is 99.997%, in accordance with knowledge from the U.S. Facilities for Illness Management and Prevention, cited by Dr. Reid Sheftall.18 What this heartbreaking loss ought to set off, nevertheless, is elevated investigation into why a beforehand wholesome teenager died so unexpectedly from a virus that’s not often harmful in that age group.

In an interview, her mom said that she had gotten a flu shot. May this have been a consider her physique’s extreme, and finally deadly, response to the virus? It’s unattainable to know, however given the growing analysis suggesting flu vaccination could worsen viral sickness, it’s a connection that should be thought of.

Analysis revealed within the Journal of Virology in 2011, as an illustration, discovered that seasonal flu vaccine could weaken kids’s immune techniques and enhance their probabilities of getting sick from influenza viruses not included within the vaccine.

“[L]ong-term annual vaccination utilizing inactivated vaccines could hamper the induction of cross-reactive CD8+ T cell responses by pure infections and thus could have an effect on the induction of heterosubtypic immunity. This will likely render younger kids who haven’t beforehand been contaminated with an influenza virus extra inclined to an infection with a pandemic influenza virus of a novel subtype,” the researchers famous.19

Flu Photographs May Be ‘Potential Contributors’ to Pandemic

Dr. Allan S. Cunningham, a retired pediatrician, reiterated what the information bear out — that flu vaccines must be evaluated as potential causative brokers or, a minimum of, contributors to the COVID-19 pandemic. In a speedy response to an article revealed by The BMJ, he said:20

“A randomized placebo-controlled trial in kids confirmed that flu photographs elevated fivefold the danger of acute respiratory infections attributable to a bunch of noninfluenza viruses, together with coronaviruses21

Such an remark could seem counterintuitive, however it’s attainable that influenza vaccines alter our immune techniques non-specifically to extend susceptibility to different infections; this has been noticed with DTP and different vaccines.22 There are different immune mechanisms that may additionally clarify the remark.

To analyze this chance, a case-control research is so as … Influenza vaccines have develop into sacred cows in some quarters, however they shouldn’t be.”

In the meantime, within the U.S. the CDC reported that the share of respiratory specimens submitted for influenza testing that check optimistic decreased from better than 20% to 2.3% for the reason that begin of the pandemic.23 Briefly, flu has primarily disappeared, for causes unknown. However even whereas stating that flu circumstances are subsequent to nonexistent this season — they nonetheless need you to get your flu shot, “particularly this season.”24